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Agilent expands use of HPLC chip

Posted: 28 Feb 2007     Print Version  Bookmark and Share

Keywords:spectrometer  Agilent  HPLC chip  high-performance liquid chromatography chip  mass spectrometers 

Agilent Technologies Ltd has expanded the use of its high-performance liquid chromatography (HPLC) chip to its triple quadrupole (QQQ) and quadrupole-time of flight (Q-TOF) mass spectrometers, enabling the chip and mass spectrometer systems to perform small molecule analysis. This also signals the completion of the chip's expansion across Agilent's entire liquid chromatography (LC) and mass spectrometry (MS) portfolio.

HPLC chip technology is a form of LC separation that replaces conventional LC nanoflow column and microvalves with a simple, compact microfluidics chip. Smaller than a credit card, the chip integrates the sample enrichment and separation capability of a nanoflow LC system with the single emitter per instrument and intricate connections used for electrospray MS. The technology also cuts 50 per cent of the fittings and connections required in nanoflow LC/MS systems, reducing possible leaks and dead volumes, while improving ease-of-use, sensitivity, productivity and reliability during analysis.

The HPLC chip technology delivers stable, reproducible nanospray, critical for high-sensitivity quantitative QQQ applications for small molecules. The expansion allows researchers to move beyond the HPLC chip's early protein-identification applications to the small molecule arena.

"Where sample size is limited, quantitative nanospray on the QQQ will offer special opportunities, providing substantial savings to customers in sample preparation alone," said Agilent's Fred Strohmeier, VP and general manager, liquid phase separations division. It will have special use for life sciences, environmental and forensic applications, where researchers often deal with low amounts of sample."

Adds Strohmeier, "For these applications, conventional nanospray isn't reliable enough for routine use and is difficult to implement and maintain. With the HPLC chip, in combination with Agilent's LC/MS portfolio, it's finally accessible for these applications—and in a remarkably easy-to-use format."

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